Home About us The need
The need
E-mail Print PDF
Font SizeLarger FontSmaller Font

Over 50,000 Australians suffer from profound blindness and are termed “legally blind”. The major cause of profound blindness is degeneration of the cells in the eye that receive light signals. It has been estimated that the cost of profound vision loss in Australia is upwards of $2.5billion p.a. The equivalent global figures are much bigger.

Preliminary research indicates the greatest issues for patients with profound vision loss are mobility and independence, particularly when they have had this ability before losing their sight. Other issues include the inability to recognise faces, detect objects and perceive depth or contrast.


Developing a bionic eye

Developing a bionic eye suitable for human use involves many steps and processes. The six steps that the Bionic Vision Australia partnership will implement to deliver a functioning bionic eye is shown here.



 
1. Device development
Device development is a critical research step in this project

The first advanced prototype and second prototype are being developed concurrently by the UNSW and NICTA researchers. Device development is a significant component of the research, and involves strong collaboration across the research team.

Core activities in device development
  • Development of the implant, including a hybrid device suitable for surgical implantation
  • Development of the radio frequency communications link
  • Manufacture and assembly of the first prototypes
  • Determine the most appropriate way to power the device
2. Stimulation strategy development
Stimulation strategies determine how the device stimulates the optic nerve
Stimulation strategies will ultimately determine the interaction between the bionic eye and the signals interpreted by the brain. The team’s experience in this area has been built over many years.

Core activities in stimulation strategy development
  • Development of electrical stimulation strategies to determine the most functional means of stimulating the optic nerve using interpreted light signals
  • Development of an externally worn vision processor with camera
  • Integration of electrical stimulation and vision processing, potentially using other enhancers such as voice or face recognition software
3. Surgical procedure development
Surgical procedure development is important to understanding patient views, and how the device will be implanted

In order to develop surgical procedures, a “dummy” device is required. This consists of a non-functional but materially identical prototype from which surgical procedures can be developed in animals.

Core activities in surgical procedure development
  • Use a non-functioning device (dummy device) to develop an appropriate surgical implantation procedure in animals
  • Use a functioning device to refine the surgical procedures for humans
  • BEI and CERA to play a lead role in development of surgical procedures
4. Preclinical testing (animal, efficacy and biocompatibility)
Testing includes preclinical (animal) and clinical (human) implantation

The preclinical testing phase involves implantation of the prototype into animals to determine biocompatibility and efficacy of the device and materials. Human trials would only take place once the animal testing has been successfully completed. After human trials, full scale pivotal human trials can commence.

Core activities to undertake preclinical testing (animals)
  • A bionic eye would be implanted into cat and rodent to test for cytotoxicity of materials
  • Chronic (permanently implanted) testing in animals will determine biocompatibility of materials, and device efficacy
  • The device would be modified post animal implantation in a process of continuous improvement

Valid XHTML 1.0 Transitional Valid CSS! Level A conformance icon, 
          W3C-WAI Web Content Accessibility Guidelines 1.0